Does your blog have a name?
It sounds like a silly question, but it's really not. Does your blog have a name? In the admin section of most blogging platforms, there's a field for the blog's name. It often defaults to something general like "new site" or its URL. If you remove this default name, but don't replace it with anything, then your blog doesn't have a name.
Why is this a problem? Your blogging platform uses the name you give it. This name will likely be used for part of the page title on all your pages, for the title of the site's RSS feed, and several other key elements. Without a name, these elements are empty or non-existent.
This is bad? When one of your viewers has more than one tab open in their browser, the page title is what appears on the tab. Do you want this to show "My Site's Name - Home" or just "Home"? Do you want subscribers to your RSS feed to see "My Site's Name" or "Unknown" for the name of your content? To make matters worse, some RSS Feed readers have a hard time subscribing to feeds with no name element. So not only will your readers have difficulty identifying who's feed it is, some won't be able to read it at all.
Some of you are thinking, "...but I don't want my title to display in the header!" That's another issue altogether. Displaying the site's name is a theme issue. Having a name to display is site configuration. Give it a proper name and give yourself the benefit of a fully functional site. If you don't want to display the title, have someone disable the title in your theme. It should only take a minute or two.